The RAW photo processing is robust, and there are lots of controls to adjust photos, but there are some complaints about the stability and speed of the program. There's also a great photo organization tool included in Darktable. Darktable is more of a Lightroom competitor as it focuses on non-destructive editing over other photo manipulation, but for many photographers, it may do the trick. Like GIMP, it's free, but it's not as powerful. Darktableĭarktable is a suitable option for those looking to edit and export RAW files. Many users install Krita alongside GIMP to provide a powerful but free suite of software that covers all their image editing and creation needs. It's also stable enough for prolonged use. The app has recently been offered on the Epic Games Store too, increasing its audience. Available on Mac, Windows and Linux, Krita has a ton of features that should appeal to pros, like brush stabilization, extensive brush customization, HDR painting and animation.įrequently updated, Krita supports multiple monitors and tablet inputs. Krita is an open-source application ideal for content creation, illustrations, painting, sketching, comic books, concept art and more. There's also a fairly large community of users, and thorough documentation making it a good tool for power users and photo enthusiasts. It's customary to cringe at the name of this multi-platform application, which is an acronym for the "GNU Image Manipulation Program." Look past the name, and there's a lot to like here.Īvailable on Windows, Linux, and macOS, GIMP is a free photo editing tool with the ability to have masks, layers, color adjustments, and a huge library of plug-ins. Some are free, others are online-only, there are some multiplatform choices and platform exclusive options as well, so take a read-through and try some of these useful photo editing tools. Suffice to say, Adobe's tactics have left some looking for an alternative, and we have a pretty thorough list to check out. PSD you created after your subscription ends, you'll have to re-up. And like other subscription services, you don't get to keep the software, so if you want to edit a. Ever since Adobe moved to a subscription model, it can cost between $10 and $20 per month to use Photoshop or Adobe's other photo editing apps. It is “demoware,” so you can try it before you buy.While many professionals swear by Adobe's photo editing tools, others find it a bit overkill, either in terms of usability and interface or price. MacDailyNews Take: MacDailyNews has been using Pixelmator exclusively in place of Adobe Photoshop since early December 2007 for online graphics. Much more in the full article – highly recommended – here. Moore reports, “Make no mistake, this is one serious and very good graphics application for $59.95.” “Anyway, I find myself more and more likely to choose Pixelmator for graphics editing chores, partly because it starts up quickly – a very respectable 13 seconds on my 1.33 GHz G4 PowerBook (Photoshop Elements – go make a coffee – well actually about 40 seconds), a distinction that looms larger when you’re using older, slower hardware like I am, but also because once it’s up and running, I can usually accomplish what I need to do quickly and efficiently using Pixelmator’s powerful tool inventory, which I like more and more as I become increasingly familiar with it,” Moore reports. Pixelmator is still better looking, in my estimation, but Elements 6’s more subdued charcoal is arguably more functionally practical,” Moore reports. “In comparing the two programs, it’s impossible not to infer that Adobe seems to have taken serious notice of Pixelmator, since Photoshop Elements 6’s revised interface appearance, which had been generally ho-hum and bland in previous versions, has received a radical facelift and now sports a charcoal background theme, which obviously has a flattering resemblance to Pixelmator’s stunningly gorgeous obsidian black interface theme. Adobe has kindly supplied me with a prerelease beta copy of Elements 6, and what was already the class of the field in affordable bitmap programs for the Mac is now even more powerful, polished, attractive, and impressive, but Pixelmator (version 1.1.3 of which was released last week) is coming on strong as well,” Moore reports. “And speaking of Photoshop Elements, the bar is about to be raised substantially with the imminent release of Elements 6 for the Mac. The developers say their target is to make Pixelmator a Photoshop challenger – and that isn’t just hype (if they’re talking Elements rather than CS),” Charles Moore reports for Low End Mac. “I’ve been following Pixelmator’s development since I first downloaded it last summer, and I’ve found it to be both the most visually arresting graphics program I’ve ever encountered in terms of user interface aesthetics and also very capable and likable in a functional sense.
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The software is categorized as Desktop Tools. Our antivirus check shows that this download is malware free. Three-dimensional dolphins playing on your screen. You can run this PC software on Windows XP/Vista/7/8/10/11 32-bit. Windows / Desktop / Screensavers / Living 3D Dolphins ScreenSaver / Download. It works on the lock screen too!ĭolphins Live Wallpaper □ Ocean HD Wallpapers can be applied as a blue water 3D wallpaper or 4D wallpaper. Description Our software library provides a free download of Dolphins 3D Screensaver 1.1.0.9. The HD live wallpapers work on most Android phones, such as Samsung Galaxy phones, and can be used as p5w backgrounds, Xiaomi live wallpapers, wallpaper for Oppo phones and more! 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Go grab the free update, or if you’re somehow a new user, it’ll run you $5 on the iOS App Store. These days Tapbots, LLC was release Social & Communications app for Windows 10 (Mac, iPhone, iPad, Apple Watch, Twitter). The new “Night” theme in particular is darker than before, and quite pleasing to the eye for it. and dont want to spend any cash, you can get it for free in the App Store. Filter by these if you want a narrower list of alternatives or looking for a specific functionality of Tweetbot. Why Choose Tweetbot - Blazing Fast Performance. Tweetbot is an award-winning Twitter client for iOS and the Mac. Get Tweetbot for Twitter for iOS latest version. Tweetbot will continue to improve as the new API does. People who want power features will love it, others can use the free. Download Tweetbot for Twitter App 7.1.1 for iPad & iPhone free online at AppPure. Version 7 is built on Twitter’s V2 API which includes features like the ability to view Twitter polls, cards, and more tweet data. Tweetbot alternatives are mainly Twitter Clients but may also be Social Networks or Microblogs. Tweetbot is an award-winning Twitter client for iOS and the Mac. Ability to add descriptions to images when composing. Tweetbot is one of the best Twitter apps for iPhone, and arguably one of the. Other interesting Android alternatives to Tweetbot are Echofon for Twitter, Fenix for Twitter, Janetter and UberSocial.Concluding the review I would say that Tweetbot 3 is a must have app for someone who has been using the previous version. Needless to say that the iPad edition of the app will be available separately and you will have to purchase it. Auto video playback in the timeline (which can be disabled in the settings). Tweetbot 3 is only available for iPhone and iPod touch right now and iPad version will be released soon as well.Optimized dark theme for OLED displays.GIF support in compose view (Powered by Giphy).With today’s update, Tweetbot brings a new icon to match the one that shipped with the Mac update back in April, along with several other additions: It means there'll be bugs - and they'd welcome you to report them - and there won't be Mac App Store specific features like iCloud sync or Mountain Lion. Alpha is what comes before beta, and way before Mac App Store release. But here's the thing - it's not for sale yet, it's a free alpha version. Today, Tweetbot 5 for iOS was released, and it’s a totally a free updated for Tweetbot 4 users (wow, I just realized it’s been 3 whole years since that update). Tweetbot, our favorite iPhone and iPad Twitter app for power users, has just hit the Mac. Despite Twitter’s ongoing attempts to needlessly hobble 3rd-party clients, I still get excited to see our favorite one continuing to release updates. We've looked at some of the hidden iOS 16 changes that haven't gotten as much publicity while also previewing the new lock screen, Maps updates, Siri changes and more. You can get our first impressions in our iOS 16 public beta hands-on review. The Maps, Photos, Notes and Safari apps all gain new features as well. Highlights of the new release include changes to the lock screen that let you customize it, the ability to edit text messages in the Messages app, and new mobile payment features in Wallet. iOS 16 public beta: What to expectĪpple previewed iOS 16 during June's Worldwide Developer Conference. Just head there to download any new versions of the iOS 16 beta if you're already running a version of that iPhone software. Subsequent updates will be available through the Software Update section of the Settings app. The process is much simpler once you install that initial beta. After a restart, your phone will be running the iOS 16 public beta. It comes with the most recent version of WebKit, the. In the words of the install package: Safari Technology Preview gives you an early look at upcoming and improved web technologies, including HTML, JavaScript, and CSS. (If you're signing up to the Beta Software Program, just follow the onscreen instructions for registering your device - you'll just need your Apple ID.) It seems Apple likes to change the tools, so I guess it’s moved over to something separate called Safari Technology Preview. On your iOS device, go to the Beta Software Program page (opens in new tab) in your browser and log in or sign up. The first step will be to sign up to the Apple Beta Software Program.ġ. Once your iPhone is backed up, you're ready to begin. We'd recommend the latter for backing up before a beta download. We've got instructions on how to back up your iPhone, whether it's to iCloud or to a computer. With an archived backup of your iPhone, you can always revert to the old version if things don't go as planned. How to download the iOS 16 public betaĪssuming you've got a supported phone, you should first backup your iPhone before you go any further. The 7th gen iPod touch won't be able to run iOS 16, either. That means the original iPhone SE, the iPhone 6s and 6s Plus and the iPhone 7 and 7 Plus are all out, after supporting iOS 15. You'll need an iPhone 8 or later for iOS 16. IOS 16 supported devices aren't as numerous as the phones that are able to run iOS 15. Safari Technology Preview Ios is giving you objective and trustworthy reviews, and suggestions with the hope of helping you become a wise user on the Internet. However, if you want to get daily newsletters or notifications from us about the fields you’re interested in, take a few seconds to sign in.How to install the iOS 16 public beta: Supported devices Get the latest layout technologies, visual effects, developer. No, we do not require users to sign in to search and acquire more information about Safari Technology Preview. Safari Technology Preview gives you an early look at upcoming web technologies on Apple platforms. Our strong team will need more time to work with your ideas or reviews before sharing them on ReviewsGuide to make sure that other users can get the most trustworthy information about Safari Technology Preview here! Our email address: Do I have to sign in before accessing more details about Safari Technology Preview in ReviewsGuide? We always appreciate your contributions, so if you have any ideas or reviews about Safari Technology Preview, please share them with us. Can I contribute any ideas or reviews about Safari Technology Preview at ReviewsGuide? Besides having the latest web features and bug fixes from WebKit, Safari Technology Preview includes the latest improvements to Web Inspector, which you can use to develop and debug your websites. Should you have any problems and need support from us, feel free to contact us via email: You will try to respond to your matters as soon as possile within 24 hours after receiving your email. Safari Technology Preview is a standalone application that can be used side-by-side with Safari or other web browsers, making it easy to compare behaviors between them. At ReviewsGuide, we always try to synthesize all the latest trends or update more reviews so that allows you to find the most suitable information that you’re concerned about Safari Technology Preview. FAQs Can I find the latest reviews or information about Safari Technology Preview? Meanwhile, let’s have a look at a few ways to make your videos load faster. Remember, most video post-production for reducing video size happens during encoding. Again, this factor is automatically determined by the codec. The type of compression determines the ratio of size to quality of your video. However, you’ll want to maintain the quality of your videos when you make them smaller. In fact, there are a few ways that you can reduce the size of your videos. In part, you can accomplish this task by reducing your video file size. You want to create the best user experience possible for your videos. Whether you’re a website owner, an agency, or you just want to get in on our affiliate program, we have a plan for you! How to Reduce Video File Size Meanwhile, audio has its own bit rate.Īt Swarmify, our mission is to bring an accelerated, distraction-free video experience to websites of all sizes. There are two kinds of bit rate classes for video, standard dynamic range (SDR) and high dynamic range (HDR). You’d measure bit rate in kilobytes per second (Kbps). Meanwhile, a lower-quality video has a lower bit rate. It controls the size of a video file.Ī higher-quality video file has a higher rate. The bit rate is also called the data rate. These are the standard FPS for television and video content. Typically, videos have the following FPS: It’s measured in frames per second (FPS). The frame rate is the frequency of separate images in your video. The lower the resolution, the smaller the file size. There are a few common screen resolutions. In that case, it has 768 horizontal lines. The smaller the resolution, the smaller the file.įor instance, imagine that your video has a resolution of 1366 x 768. This video characteristic is measured by width and height. The resolution of a video is how many horizontal lines are in a video file in each frame. The following are some of the characteristics that video codecs affect. The codec figures out the compression ratio quality to file size. In other words, it’s software to reduce video size, compress, and decompress videos.Ĭodecs use various compression algorithms. In digital video speak, codec means compression/decompression. We’ll also explain lossy compression in a moment, but what you need to know now is that when you compress mp4 video to a smaller size with a free service, it’s transcoding, or lossy, compression. Typically, this process is a “lossy” type of compression. Transcoding involves changing your video from one form of encoding to another one. You can also add chapters, filters, subtitles, and meta-information to your video during encoding. If your brand publishes videos, there are two other important terms that you need to know-encoding and transcoding.Įncoding is the process of formatting a video for output. Right now, let's look at a few important terms. We’ll get deeper into the technical aspects of bit rate in a moment. These characteristics may include:Īlthough these characteristics are very important, the bit rate is more fundamental. It’s important to understand that bit rate is different from other important video characteristics. In other words, it’s the amount of information in a video every second. The bit rate of a video is the depth of information for both audio and video. The data per second in a video is called the bit rate. It has both lower audio and video quality.Īs you can see, these two kinds of videos have two very different amounts of data per second. If you were to produce high-quality 4K videos on DVDs, for instance, every second would pack a massive amount of data.Īlternatively, live streaming video media has much less information per second. Bit Rate Matters TooĮvery second of your video could be packed with digital information. The smaller the file, the faster your viewers can download them. In short, file compression makes video files smaller. However, they’re easy enough to understand with a bit of explanation, which you’ll get today. If you’ve never worked with video compression software, the terms surrounding the task might seem confusing. Here, we’ll go over how to tweak your videos for optimal loading. As a result, in addition to creating eye-catching videos, a technology called video compression is just as important as making sure that your audience sees your content. These kinds of big files can slow down upload and download speed. However, video files are still relatively larger than audio files and images. As it does, so does our information-sharing capability.įor example, internet speeds are faster than ever before. Keep reading to learn more about reducing video file size for streaming. Your feature-rich video production will slow most consumers’ devices down unless you reduce the video file size. The best video marketing in the world will do your brand no good if your audience can’t view it. But today Chile is a vibrant country and I was shown the ropes by someone who had studied abroad there and knew his way around. Like many of its neighbors, Chile was not immune to dictatorship in the 20th century and itself saw some turbulent times under General Pinochet following his coups against Allende. Chile is a long narrow country in South America, home to famous wines, a desert and of course Patagonia (shared with Argentina). You don’t need to download an individual bus app or train app, Moovit is your all-in-one transit app that helps you find the best bus time or train time available.įor information on prices of Bus and Metro, costs and ride fares to Mastodonte, please check the Moovit app.A few weekends ago I ventured off to Chile. We make riding to Mastodonte easy, which is why over 930 million users, including users in Valparaiso, trust Moovit as the best app for public transit. Get directions from and directions to Mastodonte easily from the Moovit App or Website. Want to see if there’s another route that gets you there at an earlier time? Moovit helps you find alternative routes or times. These are the lines and routes that have stops nearby. You can get to Mastodonte by Bus or Metro. Looking for the nearest stop or station to Mastodonte? Check out this list of stops closest to your destination:Ĭondell Intendencia De Valparaiso Errazuriz - Gomez Carreño / Oriente Errazuriz - Bellavista / Oriente Errazuriz - Duoc Cousiño / Poniente Estación Plaza Sotomayor Puerto. View schedules, routes, timetables, and find out how long does it take to get to Mastodonte in real time. Moovit provides free maps and live directions to help you navigate through your city. Wondering how to get to Mastodonte in Valparaiso, Chile? Moovit helps you find the best way to get to Mastodonte with step-by-step directions from the nearest public transit station. Public Transit to Mastodonte in Valparaiso The ASCENSOR EL PERAL is the last Funicular that goes to Mastodonte in Valparaiso. What time is the last Funicular to Mastodonte in Valparaiso?.The ASCENSOR EL PERAL is the first Funicular that goes to Mastodonte in Valparaiso. What time is the first Funicular to Mastodonte in Valparaiso?.The 901 is the last Bus that goes to Mastodonte in Valparaiso. What time is the last Bus to Mastodonte in Valparaiso?.The 201 is the first Bus that goes to Mastodonte in Valparaiso. What time is the first Bus to Mastodonte in Valparaiso?.The L1 is the last Metro that goes to Mastodonte in Valparaiso. What time is the last Metro to Mastodonte in Valparaiso?.The L1 is the first Metro that goes to Mastodonte in Valparaiso. What time is the first Metro to Mastodonte in Valparaiso?.The Estación Plaza Sotomayor station is the nearest one to Mastodonte in Valparaiso. What’s the nearest funicular station to Mastodonte in Valparaiso?.The nearest funicular station to Mastodonte in Valparaiso is a 11 min walk away. How far is the funicular station from Mastodonte in Valparaiso?.The Condell, 1298 stop is the nearest one to Mastodonte in Valparaiso. What’s the nearest bus stop to Mastodonte in Valparaiso?.The nearest bus stop to Mastodonte in Valparaiso is a 3 min walk away. How far is the bus stop from Mastodonte in Valparaiso?.The Puerto station is the nearest one to Mastodonte in Valparaiso. What’s the nearest metro station to Mastodonte in Valparaiso?. The nearest metro station to Mastodonte in Valparaiso is a 12 min walk away. How far is the metro station from Mastodonte in Valparaiso?.These Metro lines stop near Mastodonte: L1. Which Metro lines stop near Mastodonte?.Puerto is 866 meters away, 12 min walk.Estación Plaza Sotomayor is 839 meters away, 11 min walk.Errazuriz - Duoc Cousiño / Poniente is 414 meters away, 6 min walk.Errazuriz - Bellavista / Oriente is 372 meters away, 5 min walk.
Now install and open the 5KPlayer application.If you are using Mac OS X, then download the Mac version of 5KPlayer. If you are using Windows OS, then download the Windows version. Next, install the 5KPlayer on your PC.There are several UPnP apps like BubbleUPnP, AllCast, Media House UPnP, etc. These are BubbleUPnP, AllCast, Media House UPnP, etc. Then there are certain applications that leverage the DLNA media streaming. This means the sending device and the receiving device should support DLNA. First, check if your PC and Android device are DLNA compatible.Here are the steps to play a video from your Android device to your PC using 5KPlayer: Steps to Play Android Video on PC with 5KPlayer The options are endless and video quality offered is high end.ĥKPlayer is Powered by NVIDIA, INTEL, DXVA 2.0 Hardware-acceleration, which is nothing but the most efficient utilization of a computer hardware in delivering certain functions more efficiently than is possible in a software running on a general purpose CPU. The AirPlay Mirroring software facilitates instant screen mirroring of the screens of iPhone, iPad to your PC or from Mac OS X/ PC to Apple TV. If you are using Mac OS or iOS, then you have another great option to venture into. It also let you explore the humongous collections of music and videos. The main function of these three components is to function with combined efforts and help you share MKV AVC Webm 3GP VP8/9 AAC video music from Android device to PC (Windows or Mac OS X).Ī DLNA player streams H.264/MP4 MP3 AAC media on PC to smart TV, PS 3/4, Xbox, etc. DLNA leverages digital home entertainment to a great extent and thus 5KPlayer being DLNA player can be your ultimate choice.ĥKPlayer is a great combination of DLNA controller, DLNA server and DLNA rendered- the three pillars of any DLNA player. We stream media files from mobiles to PC, from PC or mobile to Smart television, from mobile to speakers and home theatres. We are quite accustomed with the terms streaming. Digital Living Network Alliance or DLNA is the backbone of any home entertainment device. The most intriguing feature of this software application is the DLNA feature. It is not just a video audio player but much more than that. 1.5KPlayer is a highly efficient, platform compatible media streaming software that has a plethora of interesting features. They are all simple to set up and use with a variety of TVs. There are several different apps that you can use to mirror your iPhone screen to a larger display. What are the best screen mirroring apps for iPhone and iPad? Screen mirroring reflects your screen onto the target display, and whatever you do will also show up on the receiving end. Moreover, the content is not transmitted from your phone or tablet but instead downloaded and played on the device you cast to. When you cast your screen to another display, you can continue using your device without affecting the cast’s content. This is different from screencasting in two ways. Whatever you see on your screen will be exactly replicated upon the display at the receiving end as if it is a mirror. What is screen mirroring?Īs the term suggests, screen mirroring is a technique to “mirror” your phone, tablet, or computer screen to a larger TV screen. But if you have some other television, you can benefit from using some of these best screen mirroring apps for iPhone and iPad. If you have Apple TV, screen mirroring is a breeze thanks to AirPlay. It’s convenient for presentations, watching videos or photo slideshows, and more. Screen mirroring involves showcasing the content from one screen – such as an iPhone or iPad – to another, preferably larger, display such as a television. Not anymore, our version is HTML5 and works in any modern web browser. Play online game Swords And Souls unblocked for free on the computer with friends at school or work. Do I need Flash to play Swords and Sandals? You can play the full version for free at CrazyGames. Where can I play the full version of Swords and Sandals? You can play Swords and Sandals for free in your web browser, no downloads required. FAQ Can you still play Swords and Sandals? Dark Souls is a third-person, action-RPG genre game developed by. Flash payer games unblocked games, unblocked games. Swords and Sandals 1 is created by eGames. Play unblocked games at school and have fun Ultimate War Unfair Mario Play unblocked games for free.
The Z allele causes the AAT protein to polymerize in hepatocytes, limiting secretion into the circulation, resulting in plasma levels 10% to 15% of the levels of normal M homozygotes ( 4, 5, 7, 29– 31).ĪAT binds serine proteases through its active site centered at methionine (M) 351 and 358 (M358, M351) through an irreversible interaction that inactivates both the protease and AAT ( 32, 33). Although there are more than 120 known alleles of AAT, individuals homozygous for the Z allele (E342K) account for more than 95% of clinically recognized cases of AAT deficiency ( 2, 4, 6, 23, 26– 28). The normal M alleles are present in more than 98% of the population ( 3, 5). Low serum levels of AAT, and thus in the alveolar structures and alveolar epithelial lining fluid (ELF), are associated with an imbalance between AAT and neutrophil-released proteases, leading to the slow destruction of the lung parenchyma ( 1, 2, 4, 6, 9, 14, 16, 23).ĪAT deficiency is caused by mutation in the SERPINA1 gene, a member of the serpin family of antiproteases ( 3, 5, 24, 25). However, hepatocytes produce the vast majority of functional AAT as AAT-deficient patients who receive liver transplants convert to the donor AAT phenotype ( 20– 22). In the lung, AAT is also produced locally by monocytes, macrophages, alveolar epithelial type 2 cells, and bronchial epithelial cells ( 17– 19). AAT is produced predominantly in the liver and diffuses across the lung from the circulation ( 1, 2, 4, 6, 9, 14– 16). AAT is a serine protease inhibitor that functions to inhibit neutrophil elastase (NE) as well as other neutrophil-released serine proteases, including proteinase 3, α-defensins, and cathepsin G ( 1, 2, 6, 9– 13). The disease, which is accelerated by smoking, presents at ages 35 to 40 in smokers compared with ages 55 to 60 in nonsmokers ( 1, 3, 6– 8). The primary manifestation of AAT deficiency is early-onset panacinar emphysema. Graphical AbstractĪlpha 1-antitrypsin (AAT) deficiency is a common autosomal recessive disorder affecting 1/2000 to 1/5000 individuals, about 90,000 people in the United States ( 1– 5). 8/AVL represents a second-generation gene therapy for AAT deficiency providing effective antiprotease protection even with oxidant stress. 8/AVL serum and ELF retained serine protease–inhibitory activity despite oxidant stress while 8/AMM function was abolished. High, dose-dependent AAT levels were found in the serum and lung epithelial lining fluid (ELF) of mice administered 8/AVL or 8/AMM by IV or IPL. 8/AVL was administered via intravenous (IV) and intrapleural (IPL) routes to C57BL/6 mice. We hypothesized that a onetime administration of a serotype 8 adeno-associated virus (AAV8) gene transfer vector coding for the oxidation-resistant variant AAT (A213/V351/元58 8/AVL) would maintain antiprotease activity under oxidant stress compared with normal AAT (A213/M351/M358 8/AMM). In vitro studies using amino acid substitutions demonstrated that replacing M351 with valine (V) and M358 with leucine (L) on a normal M1 alanine (A) 213 background provided maximum antiprotease protection despite oxidant stress. Cigarette smoke, pollution, and inflammatory cell–mediated oxidation of methionine (M) 351 and 358 inactivates AAT, limiting lung protection. AAT inhibits serine proteases, including neutrophil elastase, protecting the lung from proteolytic destruction. 2010 11:136.Alpha 1-antitrypsin (AAT) deficiency, a hereditary disorder characterized by low serum levels of functional AAT, is associated with early development of panacinar emphysema. Therapeutic efficacy of alpha-1 antitrypsin augmentation therapy on the loss of lung tissue: an integrated analysis of 2 randomised clinical trials using computed tomography densitometry.
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